Pickles Knee Study—A prospective imaging study of cruciate retaining and substituting knee replacement, in osteoarthritis and healthy aging

This study aims to examine knee kinematics before and after knee arthroplasty and compare those to the kinematics of knees in a non-arthritic age-matched cohort. In the past the only way of measuring knee kinematics accurately in three planes was to implant RSA beads or use of bone pins. These methods are both highly invasive. In this study, we aim to overcome this problem by using an image registration technology developed at within our unit with collaboration from University of Canberra and UNSW Canberra. This technique involves reregistering a 3D CT to a 2D video fluoroscopy. This study is unique because, for the first time, knee replacement patients will have their knee kinematics accurately measured both before and after surgery. Participants have their knee scanned while they perform a number of loaded end-of-range activities which will allow us to see how the knee kinematics change following surgery compared to normal. Osteoarthritic patients are randomised to receive one of three different design of implant. Postoperative testing is being done by the TORU staff in combination with the medical imaging department at The Canberra Hospital.

This study has been funded by the Canberra hospital Private Practice Fund, the University of Canberra and ZimmerBiomet.