Denisse Leyton was awarded her PhD in 2008 for a study undertaken at Monash University on autotransporters, a superfamily of bacterial outer membrane proteins typically found in bacterial pathogens responsible for infectious diseases such as diarrhea, whooping cough, cholera, chlamydia, and bacterial meningitis. Here she identified two novel autotransporter proteins and determined how their function contributed to bacterial virulence. Denisse then moved to the University of Birmingham (UK) for a post-doctoral position where her research efforts focused on the mechanisms underpinning autotransporter secretion. She was attracted back to Monash University in 2011 under an ARC Super Science Fellowship scheme to research the nanotechnology of autotransporter secretion. Denisse was awarded the 2012 Bede Morris Fellowship for Early Career Research from the Australian Academy of Science to travel to the Institut Pasteur in Paris for 12 weeks to acquire knowledge and expertise of a variety of biochemical and biophysical methods that she has applied to her current research. In 2015, Denisse took up a joint appointment between The Australian National University Research School of Biology and Medical School where she will teach Microbiology to medical students. At The ANU, her research group will focus on understanding the mechanisms of autotransporter assembly, their function, and on their reengineering for biotechnological applications.
- Drobnak, I, Braselmann, E, Chaney, J et al 2015, 'Of linkers and autochaperones: an unambiguous nomenclature to identify common and uncommon themes for autotransporter secretion', Molecular Microbiology, vol. 95, no. 1, pp. 1-16.
Microbiology to Year 1 and Year 2 MChD students