Associate Professor Jeffrey Looi

MBBS(Syd), MD(ANU), FRANZCP, AFRACMA
Associate Professor
Senior Staff Specialist, Older Persons Mental Health Service
Acting Head Academic, Unit Psychiatry and Addiction Medicine

Associate Professor Jeffrey Looi is a clinical academic neuropsychiatrist, leading an international research network on cognitive neuroscience and structural neuroimaging biomarkers in neurodegenerative and neuropsychiatric disease. He qualified MBBS (1992), and has been awarded two research higher doctorates, MD (2011) from the ANU and DMedSc (2018) from the University of Melbourne. He is board certified as a consultant physician in psychiatry (FRANZCP, 1999) and has qualifications in medical administration (AFRACMA, 2006). A Foundation Faculty member since 2003, he was appointed (2006) and continues as Associate Professor and Acting Discipline Lead (08/2016-), Academic Unit of Psychiatry & Addiction Medicine, ANU Medical School. He was appointed as a Clinical Associate Professor at the Melbourne Neuropsychiatry Centre, University of Melbourne in 2015. He works in clinical practice two days/week.

Professor Looi has received multiple international research and leadership awards, including: a Fulbright Scholarship at the Laboratory of Neuro Imaging, UCLA Medical School (2005); Australian Davos Connection Future Summit Leadership award (2006); and a Young Psychiatrist Award from the Pacific Rim College of Psychiatrists (2012). He has been a senior medico-political representative with the Australian Medical Association and Royal Australian and New Zealand College of Psychiatrists for nearly two decades; and is an author/co-author on more than 105 peer-reviewed papers and 100+ other publications (Google Scholar h-index:24, i10-index:39, citations: 2594).

The international research network he leads is AUSSIE, the Australian United States Scandinavian/Spanish Imaging Exchange. This network focuses on mentoring medical researchers in clinical neuropsychiatry and neuroscience research: especially medical students, medical scientists and physicians in training, as well as collaborative interdisciplinary research (neuroscience, computational science/engineering, medical physics, psychology, neurology, neuroradiology and psychiatry). The network is a platform for developing early career research and collaborative skills, as well as for international scientific exchange. A number of students, graduates and start-up collaborators have received local, national and international awards for their research excellence.

Specialisation

  • Psychiatry

Research interests

  • Neuropsychiatry of movement disorders, cognitive impairment and dementia
  • Structural-functional correlative magnetic resonance neuroimaging in neurodegenerative and neuropsychiatric disease: endophenotype characterisation
  • Subcortical neuroimaging biomarkers for neurodegenerative and neuropsychiatric disease
  • Manual and automated segmentation of neuroanatomic structures in brain magnetic resonance images: computational neuroanatomy
  • MRI processing, data analysis and computer visualisation
  • Cognitive neuroscience and neuroanatomy of neurodegenerative disease
  • Translational neuroimaging measures for clinical practice
  • Owens-Walton, C, Jakabek, D, Li, X et al 2018, 'Striatal changes in Parkinson disease: An investigation of morphology, functional connectivity and their relationship to clinical symptoms', Psychiatry Research: Neuroimaging, vol. 275, pp. 5-13.
  • Keightley, P, Reay, R, Pavli, P et al 2018, 'Inflammatory bowel disease-related fatigue is correlated with depression and gender', Australasian Psychiatry, vol. 26, no. 5, pp. 1-6.
  • Eratne, D, Loi, S, Farrand, S et al 2018, 'Alzheimers disease paper 1: clinical update on epidemiology, pathophysiology and diagnosis', Australasian Psychiatry, vol. 26, no. 4, pp. 347-357.
  • Loi, S, Walterfang, M, Velakoulis, D et al 2018, 'Huntington’s disease: Managing neuropsychiatric symptoms in Huntington’s disease', Australasian Psychiatry, vol. 26, no. 4, pp. 376-380.
  • Looi, J & Anderson, K 2018, 'Between SET and ASP: balancing the scales of student evaluation of teaching (SET) and teachers? assessments of student performance (ASP) for medical school education in psychiatry', Australasian Psychiatry, vol. 26, no. 6, pp. 659-661pp.
  • Goh, A, Wibawa, P, Loi, S et al 2018, 'Huntington's disease: Neuropsychiatric manifestations of Huntington's disease', Australasian Psychiatry, vol. 26, no. 4, pp. 366-375pp.
  • Loi, S, Eratne, D, Kelso, W et al 2018, 'Alzheimer disease: Non-pharmacological and pharmacological management of cognition and neuropsychiatric symptoms', Australasian Psychiatry, vol. 26, no. 4, pp. 358-365pp.
  • Jakabek, D, Power, B, Macfarlane, M et al 2018, 'Regional structural hypo- and hyperconnectivity of frontal-striatal and frontal-thalamic pathways in behavioral variant frontotemporal dementia', Human Brain Mapping, vol. 39, no. 10, pp. 4083-4093pp.
  • Looi, J & Kisely, S 2018, 'So we beat on, boats against the current, borne back ceaselessly into the past - Continued inaction on public mental health services', Australian and New Zealand Journal of Psychiatry, vol. 52, no. 9, pp. 824-825pp.
  • Power, B, Jakabek, D, Hunter-Dickson, M et al 2017, 'Morphometric analysis of thalamic volume in progressive supranuclear palsy: In vivo evidence of regionally specific bilateral thalamic atrophy', Psychiatry Research: Neuroimaging, vol. 265, pp. 65-71pp.
  • Yong, C & Looi, J 2017, '2017 RANZCP CONTINUING PROFESSIONAL DEVELOPMENT PROGRAM: IMPLEMENTATION AND PROGRESSION', Royal Australian and New Zealand College of Psychiatrists Faculty of Psychiatry of Old Age Conference 2017, SAGE Publications, United Kingdom, pp. 30-30.
  • Bulic, D, Bennett, M, Rodgers, H et al 2017, 'Delirium After Mechanical Ventilation in Intensive Care Units: The Cognitive and Psychosocial Assessment (CAPA) Study Protocol', JMIR Research Protocols, vol. 6, no. 2, pp. e31.
  • Looi, J & Santillo, A 2017, 'Time and relative dimensions in syndromology: Towards endophenotypes in neurology, psychiatry and in-between', Australian and New Zealand Journal of Psychiatry, vol. 51, no. 11, pp. 1079-1081.
  • Looi, J & Yong, C 2017, 'The doctor as an expert: Apprentice, journeyman or master', Medical Journal of Australia, vol. 207, no. 4, pp. 143-144.
  • Keightley, P, Maguire, P, Reay, R et al 2017, 'Clinical research in an academic psychiatry department: some general principles and case studies', Australasian Psychiatry, vol. 25, no. 6, pp. 596-599pp.
  • Turner, L, Jakabek, D, Wilkes, F et al 2016, 'Striatal morphology correlates with frontostriatal electrophysiological motor processing in Huntington's disease: An IMAGE-HD study', Brain and Behavior, vol. 6, no. 12, pp. 1-13.
  • Looi, J, Molina Ruiz, R, Evans, A et al 2016, 'A guide to management of neuropsychiatric manifestations of Parkinson's disease', Australasian Psychiatry, vol. 24, no. 6, pp. 534-537.
  • Johnson, K, Macfarlane, M & Looi, J 2016, 'Affective disorders and functional (non-epileptic) seizures in persons with epilepsy', Australasian Psychiatry, vol. 24, no. 6, pp. 526-528.
  • Molina Ruiz, R, Evans, A, Velakoulis, D et al 2016, 'Neuropsychiatric manifestations of Parkinson's disease', Australasian Psychiatry, vol. 24, no. 6, pp. 529-533pp.
  • Looi, J 2016, 'Neuropsychiatry: a synthesis of clinical and scientific fields for disorders of mind and body', Australasian Psychiatry, vol. 24, no. 6, pp. 523-524pp.
  • Jakabek, D, Macfarlane, M, Santillo, A et al 2016, 'SHAPE ANALYSIS USING SPHERICAL HARMONIC DESCRIPTION WITH POINT DISTRIBUTION MODELS (SPHARM-PDM): A POWERFUL TOOL FOR INVESTIGATING MORPHOLOGICAL BRAIN CHANGES', Royal Australian & New Zealand College of Psychiatry Congress 2016, Sage Publications Ltd., United Kingdom, pp. 47-48.
  • Owens-Walton, C, Jakabek, D, Wilkes, F et al 2016, 'NEOSTRIATAL MORPHOLOGY IN PARKINSON'S DISEASE: IN VIVO BIOMARKERS OF DISEASE PROGRESSION STAGES AND CLINICAL SYMPTOMS', Royal Australian & New Zealand College of Psychiatry Congress 2016, Sage Publications Ltd., United Kingdom, pp. 48-48.
  • Power, B, Nguyen, T, Hayhow, B et al 2016, 'Neuroimaging in psychiatry: An update on neuroimaging in the clinical setting', Australasian Psychiatry, vol. 24, no. 2, pp. 157-163.
  • Brakoulias, V, Macfarlane, M & Looi, J 2015, 'The rites of writing papers: Steps to successful publishing for psychiatrists', Australasian Psychiatry, vol. 23, no. 1, pp. 32-36.
  • Siskind, D, Parker, S, Loi, S et al 2015, 'How to survive in research: advice for the novice investigator', Australasian Psychiatry, vol. 23, no. 1, pp. 22-24.
  • Brakoulias, V, Macfarlane, M & Looi, J 2015, 'The rites of writing papers: Steps to successful publishing for psychiatrists', Australasian Psychiatry, vol. 23, no. 1, pp. 32-36.
  • Turner, L, Croft, R, Churchyard, A et al 2015, 'Abnormal electrophysiological motor responses in Huntington's disease: Evidence of premanifest compensation', PLOS ONE (Public Library of Science), vol. 10, no. 9, pp. e0138563-e0138563.
  • Keightley, P, Pavli, P, Platten, J et al 2015, 'Gut feelings 2. Mind, mood and gut in inflammatory bowel disease: Approaches to psychiatric care', Australasian Psychiatry, vol. 23, no. 4, pp. 407-410.
  • Keightley, P, Pavli, P, Platten, J et al 2015, 'Gut feelings 1. Mind, mood and gut in irritable bowel syndrome: Approaches to psychiatric care', Australasian Psychiatry, vol. 23, no. 4, pp. 403-406.
  • Mocellin, R, Scholes, A, Walterfang, M et al 2015, 'Clinical update on frontotemporal dementia: diagnosis and treatment', Australasian Psychiatry, vol. 23, no. 5, pp. 481-487.
  • Kisely, S, Chang, A, Crowe, J et al 2015, 'Getting started in research: systematic reviews and meta-analyses', Australasian Psychiatry, vol. 23, no. 1, pp. 16-21.
  • Looi, J, Kisely, S, Macfarlane, M et al 2015, 'A guide to clinical research supervision for psychiatrists: a mentoring approach', Australasian Psychiatry, vol. 23, no. 1, pp. 25-28.
  • Macfarlane, M, Kisely, S, Loi, S et al 2015, 'Getting started in research: designing and preparing to conduct a research study', Australasian Psychiatry, vol. 23, no. 1, pp. 12-15.
  • Looi, J & Liberg, B 2015, 'Between Scylla and Charybdis: DSM-5/ICD-11 and RDoC in neuropsychiatry?', Australian and New Zealand Journal of Psychiatry, vol. 49, no. 1, pp. 82-83.
  • Macfarlane, M, Kisely, S, Loi, S et al 2015, 'Getting started in research: research questions, supervisors and literature reviews', Australasian Psychiatry, vol. 23, no. 1, pp. 8-11.
  • Power, B, Wilkes, F, Hunter-Dickson, M et al 2015, 'Validation of a protocol for manual segmentation of the thalamus on magnetic resonance imaging scans', Psychiatry Research: Neuroimaging, vol. 232, no. 1, pp. 98-105.
  • Macfarlane, M, Jakabek, D, Walterfang, M et al 2015, 'Striatal Atrophy in the Behavioural Variant of Frontotemporal Dementia: Correlation with Diagnosis, Negative Symptoms and Disease Severity', PLOS ONE (Public Library of Science), vol. 10, no. 6, pp. e0129692-e0129692.
  • Macfarlane, M, Looi, J, Walterfang, M et al 2015, 'Shape Abnormalities of the Caudate Nucleus Correlate with Poorer Gait and Balance: Results from a Subset of the LADIS Study', American Journal of Geriatric Psychiatry, vol. 23, no. 1, pp. 59-U90.
  • Power, B & Looi, J 2015, 'The thalamus as a putative biomarker in neurodegenerative disorders', Australian and New Zealand Journal of Psychiatry, vol. 49, no. 6, pp. 502-518.
  • Walterfang, M, Luders, E, Looi, J et al 2014, 'Shape analysis of the corpus callosum in Alzheimer's disease and frontotemporal lobar degeneration subtypes', Journal of Alzheimer's Disease, vol. 40, no. 4, pp. 897-906.
  • Looi, J, Velakoulis, D, Walterfang, M et al 2014, 'The Australian, US, Scandinavian Imaging Exchange (AUSSIE): An innovative, virtually-integrated health research network embedded in health care', Australasian Psychiatry, vol. 22, no. 3, pp. 260-265.
  • Looi, J & Macfarlane, S 2014, 'Psychotropic drug use in aged care facilities: a reflection of a systemic problem?', Medical Journal of Australia, vol. 200, no. 1, pp. 13-14.
  • Looi, J, Walterfang, M, Nilsson, C et al 2014, 'The subcortical connectome: Hubs, spokes and the space between - a vision for further research in neurodegenerative disease', Australian and New Zealand Journal of Psychiatry, vol. 48, no. 4, pp. 306-309.
  • Hassan, I, Looi, J, Velakoulis, D et al 2014, 'Psychosis with obsessive-compulsive symptoms in tuberous sclerosis', Journal of Clinical Neuroscience, vol. 21, no. 5, pp. 867-869.
  • Looi, J, Byrne, G, Macfarlane, S et al 2014, 'Systemic approach to behavioural and psychological symptoms of dementia in residential aged care facilities', Australian and New Zealand Journal of Psychiatry, vol. 48, no. 2, pp. 112-115.
  • Looi, J & Velakoulis, D 2014, 'Major and minor neurocognitive disorders in DSM-5: The difference between the map and the terrain', Australian and New Zealand Journal of Psychiatry, vol. 48, no. 3, pp. 284-286.
  • Looi, J & Walterfang, M 2013, 'Striatal morphology as a biomarker in neurodegenerative disease', Molecular Psychiatry, vol. 18, no. 4, pp. 417-424.
  • Looi, J, Kisely, S, Merry, S et al 2013, 'Reviving the ethos of scientific research in psychiatric practice', Australian and New Zealand Journal of Psychiatry, vol. 47, no. 4, pp. 309-311.
  • Macfarlane, M, Looi, J, Walterfang, M et al 2013, 'Executive dysfunction correlates with caudate nucleus atrophy in patients with white matter changes on MRI: A subset of LADIS', Psychiatry Research: Neuroimaging, vol. 214, no. 1, pp. 16-23.
  • Hayhow, B, Hassan, I, Looi, J et al 2013, 'The neuropsychiatry of hyperkinetic movement disorders: insights from neuroimaging into the neural circuit bases of dysfunction', Tremor and Other Hyperkinetic Movements, vol. 3, pp. 1-13.
  • Abel, L, Bowman, E, Velakoulis, D et al 2012, 'Saccadic Eye Movement Characteristics in Adult Niemann-Pick Type C Disease: Relationships with Disease Severity and Brain Structural Measures', PLOS ONE (Public Library of Science), vol. 7, no. 11.
  • Looi, J, Rajagopalan, P, Walterfang, M et al 2012, 'Differential putaminal morphology in Huntington's disease, frontotemporal dementia and Alzheimer's disease', Australian and New Zealand Journal of Psychiatry, vol. 46, no. 12, pp. 1145-1158.
  • Looi, J, Walterfang, M, Velakoulis, D et al 2012, 'Frontotemporal dementia as a frontostriatal disorder: neostriatal morphology as a biomarker and structural basis for an endophenotype', Australian and New Zealand Journal of Psychiatry, vol. 46, no. 5, pp. 422-434.
  • Macfarlane, S, McKay, R & Looi, J 2012, 'Limited antidepressant efficacy in depression in dementia, in the context of limited evidence ...', Australian and New Zealand Journal of Psychiatry, vol. 46, no. 7, pp. 595-597.
  • Lindberg, O, Walterfang, M, Looi, J et al 2012, 'Hippocampal shape analysis in Alzheimer's disease and frontotemporal lobar degeneration subtypes', Journal of Alzheimer's Disease, vol. 30, no. 2, pp. 355-365.
  • Walterfang, M, Macfarlane, M, Looi, J et al 2012, 'Pontine-to-midbrain ratio indexes ocular-motor function and illness stage in adult Niemann-Pick disease type C', European Journal of Neurology, vol. 19, no. 3, pp. 462-467.
  • Looi, J, Macfarlane, M, Walterfang, M et al 2011, 'Morphometric analysis of subcortical structures in progressive supranuclear palsy: In vivo evidence of neostriatal and mesencephalic atrophy', Psychiatry Research: Neuroimaging, vol. 194, no. 2, pp. 163-175.
  • Walterfang, M, Looi, J, Styner, M et al 2011, 'Shape alterations in the striatum in chorea-acanthocytosis', Psychiatry Research: Neuroimaging, vol. 192, no. 1, pp. 29-36.
  • Looi, J, Walterfang, M, Styner, M et al 2011, 'Shape analysis of the neostriatum in subtypes of frontotemporal lobar degeneration: Neuroanatomically significant regional morphologic change', Psychiatry Research: Neuroimaging, vol. 191, no. 2, pp. 98-111.
  • Walterfang, M, Evans, A, Looi, J et al 2011, 'The neuropsychiatry of neuroacanthocytosis syndromes', Neuroscience and Biobehavioral Reviews, vol. 35, no. 5, pp. 1275-1283.
  • Maguire, P, Reay, R, Looi, J et al 2011, 'Neither the internist nor the Internet: Use of and trust in health information sources by people with schizophrenia', Australian and New Zealand Journal of Psychiatry, vol. 45, no. 6, pp. 489-497.
  • Looi, J, Walterfang, M, Styner, M et al 2010, 'Shape analysis of the neostriatum in frontotemporal lobar degeneration, Alzheimer's disease, and controls', Neuroimage, vol. 51, no. 3, pp. 970-986.
  • Looi, J, Pagani, M, Nardo, D et al 2010, 'Structural and Functional Neuroimaging in PTSD: A Neurobiological Update', in (ed.), Neurobiology of Post-Traumatic Stress Disorder, Nova Science Publishers Inc., New York.
  • Nardo, D, Hogberg, G, Looi, J et al 2010, 'Gray matter density in limbic and paralimbic cortices is associated with trauma load and EMDR outcome in PTSD patients', Journal of Psychiatric Research, vol. 44, no. 7, pp. 477-485.
  • Kumar, R & Looi, J 2010, 'Toxic psychosis', in Perminder S. Sachdev (ed.), Secondary Schizophrenia, Cambridge University Press, United Kingdom, pp. 179-185.
  • Raphael, B, Taylor, M, Jacobs, J et al 2009, 'Strategies for occupational mental health protection', Journal of Occupational Health and Safety: Australia and New Zealand, vol. 25, no. 1, pp. 7-17.
  • Looi, J, Maller, J, Pagani, M et al 2009, 'Caudate volumes in public transportation workers exposed to trauma in the Stockholm train system', Psychiatry Research: Neuroimaging, vol. 171, pp. 138-143.
  • Lindberg, O, Ostberg, P, Zandbelt, B et al 2009, 'Cortical Morphometric Subclassification of Frontotemporal Lobar Degeneration', American Journal of Neuroradiology, vol. 30, pp. 1233 - 1239.
  • Looi, J, Svensson, L, Lindberg, O et al 2009, 'Putaminal Volume in Frontotemporal Lobar Degeneration and Alzheimer Disease: Differential Volumes in Dementia Subtypes and Controls', American Journal of Neuroradiology, vol. 30, pp. 1552-1560.
  • Looi, J, Tatham, V, Kumar, R et al 2009, 'Caudate nucleus volumes in stroke and vascular dementia', Psychiatry Research: Neuroimaging, vol. 174, pp. 67-75.
  • Kumar, R, Looi, J & Raphael, B 2009, 'Type 2 diabetes mellitus, cognition and brain in aging: A brief review', Indian Journal of Psychiatry, vol. 51, no. Supplement January 2009, pp. s35-38.
  • Looi, J 2008, 'Empathy and Competence', Medical Journal of Australia, vol. 188, no. 7, pp. 414-416.
  • Looi, J, Lindberg, O, Liberg, B et al 2008, 'Volumetrics of the caudate nucleus: Reliability and validity of a new manual tracing protocol', Psychiatry Research: Neuroimaging, vol. 163, pp. 279-288.
  • Looi, J, Lindberg, O, Zandbelt, B et al 2008, 'Caudate Nucleus Volumes in Frontotemporal Lobar Degeneration: Differential Atrophy in Subtypes', American Journal of Neuroradiology, vol. 29, no. Sep 2008, pp. 1537-1543.
  • Jones, T, Matias, M, Powell, J et al 2007, 'Who cares for older people with mental illness? A survey of residential aged care facilities in the Australian Capital Territory: Implications for mental health nursing', International Journal of Mental Health Nursing, vol. 16, pp. 327-337.
  • Looi, J & Raphael, B 2007, 'Reflections on therapy in the era of the internet', Australasian Psychiatry, vol. 15, no. 4, pp. 334-337.
  • Looi, J, Matias, M & Ruzich, M 2005, 'Conceptualization of depression in Parkinsons disease', Neuropsychiatric Disease and Treatment, vol. 1, no. 2, pp. 135-143.
  • Ruzich, M, Looi, J & Robertson, M 2005, 'Delayed onset of posttraumatic stress disorder among male combat veterans', American Journal of Geriatric Psychiatry, vol. 13, no. 5, pp. 424-427.
  • Raymond, J, Kirkwood, H & Looi, J 2004, 'Commitment and collaboration for excellence in older persons mental health: the ACT experience', Australasian Psychiatry, vol. 12, no. 2, pp. 130-133.
  • Sachdev, P, Brodaty, H, Valenzuela, M et al 2004, 'The Neuropsychological profile of vascular cognitive impairement in stroke and TIA patients', Neurology, vol. 62, no. 6, pp. 912-919.
  • Sachdev, P & Looi, J 2003, 'Structural neuroimaging of the ageing brain', in Sachdev, Perminder S. (ed.), The Ageing Brain: the neurobiology and neuropsychiatry of ageing: the neurobiology and neuropsychiatry of ageing, Swets Zeitlinger BV, Netherlands, pp. 49-63.
  • Sachdev, P, Valenzuela, M, Brodaty, H et al 2003, 'Homocysteine as a Risk Factor for Cognitive Impairment in Stroke Patients', Dementia and Geriatric Cognitive Disorders, vol. 15, pp. 155-162.
  • Looi, J & Sachdev, P 2003, 'Geriatric psychiatry: is the jury still out on the cognitive effects of homocysteine and one-carbon metabolism?', Current Opinion In Psychiatry, vol. 16, no. 6, p. 14.
  • Looi, J & Sachdev, P 2003, 'Neuropsychological differentiation of Alzheimers disease and Vascular dementia', in Bowler, J & Hachinski, V (ed.), Vascular cognitive impairment: Preventable Dementia, Oxford University Press, New York, pp. 153-176.