Associate Professor Richard Callaghan

Associate Professor in Biochemistry
Organisational unit member - Acton Campus
134 Linnaeus Way, ANU, Acton ACT 2601
 02 6125 0825

Profile

Qualifications

BSc(Hons), PhD

Biography

I am the Group Leader of the Human Disease & Membrane Transport Laboratory in the Research School of Biology at the Australian National University in Canberra. Our research interests focus on understanding the contributions of membrane transport processes to disease and overcoming their impact in treating disease. The expertise of our research team is in the biochemical pharmacology of membrane transporters and generating structural information on these proteins. The specific projects tackled include:

1. Contributions of ABC transporters (P-gp and ABCG2) to chemotherapy resistance in cancer. 2. Does faulty retinoid transport (by ABCA4) underpin several visual disorders? 3. Malarial resistance to chemotherapy and drug translocation. 4. Adaptive changes to bioenergetic metabolism and nutrient utilisation in solid tumours

I am involved in teaching fundamental aspects of Metabolic Biochemistry to both Medical Students and Biology students at the ANU. I am also responsible for running the research project component of the Medical School syllabus.

http://biology.anu.edu.au/research/labs/callaghan-lab-human-disease-and-...

Research

Research interests

Membrane transport is essential for the growth, homeostasis and defence of cells. No better evidence of this fact is the considerable proportion of the genome devoted to membrane bound proteins. However, disruption of membrane transport often contributes to development, or progression, of many disease states. In addition, perturbations in membrane transport processes frequently contribute to the the failure of many therapeutic strategies. Our research interests focus on understanding the contributions of membrane transport processes to disease and overcoming their impact in treating disease. The expertise of our research team is in the biochemical pharmacology of membrane transporters and generating structural information on these proteins. As shown by the diagram opposite, our strategy utilises the triad of structural, functional and pharmacological endeavours. The laboratory has assembled the infrastructure and considerable expertise in enabling us to work within this triad. We have four main streams of research, so click on the appropriate one and see more details on each of the major projects that we deal with:

  1. Contributions of ABC transporters (P-glycoprotein and ABCG2) to chemotherapy resistance in cancer.
  2. Does faulty retinoid transport (by ABCA4)  underpin several visual disorders?
  3. Malarial resistance to chemotherapy and drug translocation.
  4. Adaptive changes to bioenergetic metabolism and nutrient utilisation in solid tumours

Updated:  23 August 2017/Responsible Officer:  Dean, Medical School/Page Contact:  Webmaster, Medical School